Prof.하운환
Prof.하운환
직위 또는 학위 : Ph.D. (2002), University of Florida
산학협력관 38-311
Tel : 044-860-1418
E-mail : haunhwan@korea.ac.kr
연구분야 : 감염/면역, 항균 및 항바이러스 유도 기전
· 2002 - 이학박사, 미국 플로리다대(미생물학/면역학)
· 2002 - 2003 Post-doc, 플로리다대
· 2003 - 2005 Post-doc, House Ear Institute
· 2005 - 2008 Post-doc, Univ. Rochester Medical Center
· 2008 - 2010 조교수, 고려대학교 생명정보공학과
· 2009 - 2010 편집간사, 한국미생물학회 국문지
· 2010 - 2015 부교수, 고려대학교 생명정보공학과
· 2012 - 2013 편집위원장, 한국미생물학회 국문지
· 2012 - 2013 학과장, 고려대학교 생명정보공학과
· 2014 - 방문교수, 미국 플로리다대
· 2015 - 현재 교수, 고려대학교 생명정보공학과
· 2022 - 2023 학과장, 고려대학교 생명정보공학과
Curriculum Vitae
2022
[1] Cai Z, Yang F, Shao X, Yue Z, Li Z, Song Y, Pan X, Jin Y, Cheng Z, Ha UH, Feng J, Yang L, Deng X, Wu W, Bai F. (2022) ECF Sigma Factor HxuI Is Critical for In Vivo Fitness of Pseudomonas aeruginosa during Infection. Microbiol Spectr. 10(1):e0162021. (doi: 10.1128/spectrum.01620-21).
[2] Yu H, Huh JW, Bai F, Ha UH. (2022) DnaJ-induced TLR7 mediates an increase in type I/III IFNs through the TLR4-engaged AKT/NF-B and JNK signaling pathways in macrophages. Microb Pathog. 165:105465. (doi: 10.1016/j.micpath.2022.105465)
[3] Li S, Gong X, Yin L, Pan X, Jin Y, Bai F, Cheng Z, Ha UH, Wu W. (2022) Acetylation of CspC Controls the Las Quorum Sensing System through Translational Regulation of rsaL in Pseudomonas aeruginosa. mBio e0054722. (doi: 10.1128/mbio.00547-22)
[4] Kim HB, Cho S, Lee Y, Wu W, Ha UH. (2022) Weigela florida inhibits the expression of inflammatory mediators induced by Pseudomonas aeruginosa and Staphylococcus aureus infection. J Microbiol. 60(6):649-656. (doi: 10.1007/s12275-022-1638-6)
[5] Yang F, Zhou Y, CHen P, Cai Z, Yue Z, Jin Y, Cheng Z, Wu W, Yang L, Ha UH, Bai F. (2022) High-Level Expression of Cell-Surface Signaling System Hxu Enhances Pseudomonas aeruginosa Bloodstream Infection. Infect. Immun. 90(10):e0032922. (doi:10.1128/iai.00329-22)
2021
[1]Jeon J, Lee Y, Yu H, Ha UH. (2021) Pseudomonas aeruginosa DnaK stimulates the production of Pentraxin 3 via TLR4-dependent NF-B and ERK signaling pathways. Int J Mole Sci. 22(9):4652. (doi: 10.3390/ijms22094652).
2020
[1]Jeon J, Lee Y, Yu H, Ha UH. (2020) HSP70-homolog DnaK of Pseudomonas aeruginosa increases the production of IL-27 through expression of EBI3 via TLR4-dependent NF- B and TLR4-independent Akt signaling. Int J Mole Sci. 21(23):E9194 (doi:10.3390/ijms21239194).
[2]Lee Y, Park SH, Lee JH, Ryu HW, Jang HJ, Kim WJ, Hwang E, Kim SJ, Jun HS, Ha UH. (2020) The Anti-Tumor Effects of Oenothera odorata Extract Are Mediated by Inhibition of Glycolysis and Cellular Respiration in Cancer Cells. Nutr. Cancer 1-11 (doi: 10.1080/01635581.2020.1824000).
[3]Lee JH, Jeon J, Bai F, Wu W, Ha UH. (2020) Negative regulation of interleukin 1β expression in response to DnaK from Pseudomonas aeruginosa via the PI3K/PDK1/FoxO1 pathways. Comp Immunol Microbiol Infect Dis. 73:101543 (doi: 10.1016/j.cimid.2020.101543).
[4]Lee MK, Lee Y, Huh JW, Chen H, Wu W, Ha UH. (2020) The Pseudomonas aeruginosa HSP90-like protein HtpG regulates IL-8 expression through NF-κB/p38 MAPK and CYLD signaling triggered by TLR4 and CD91. Microbes Infect. S1286-4579(20)30152-0 (doi: 10.1016/j.micinf.2020.08.005).
[5]Huh JW, Lee JH, Jeon E, Ryu HW, Oh SR, Ahn KS, Jun HS, Ha UH. (2020) Maackiain, a compound derived from Sophora flavescens, increases IL-1beta production by amplifying nigericin-mediated inflammasome activation. FEBS Open Bio. 10(8):1482-1491 (doi: 10.1002/2211-5463.12899).2019
[1]Lee JH, Jeon J, Bai F, Jin S, Wu W, Ha UH. (2019) The Pseudomonas aeruginosa HSP70-like protein DnaK induces IL-1β expression via TLR4-dependent activation of the NF-κB and JNK signaling pathways. Comp Immunol Microbiol Infect Dis. 67:101373 (doi: 10.1016/j.cimid.2019.101373).
2018
[1]Chang HJ, Shin HS, Kim TH, Yoo JY, Teasley HE, Zhao JJ, Ha UH and Jeong JW. (2018) Pik3ca is required for mouse uterine gland development and pregnancy. PLoS ONE. 13(1):e0191433. (co-corresponding)
2017
[1]Jeon J, Kim YJ, Shin H and Ha UH. (2017) T3SS effector ExoY reduces inflammasome-related responses by suppressing bacterial motility and delaying activation of NF-kappaB and caspase-1. FEBS J. 284:3392-3403.
[2]Shin H, Jeon J, Lee JH, Jin S and Ha UH. (2017) Pseudomonas aeruginosa GroEL stimulates production of PTX3 by activating the NF-kappaB pathway and simultaneously down-regulating microRNA-9. Infect. Immun. 85(3):e00935-16.2016
[1]Park JW, Kim YJ, Shin IS, Kwon OK, Hong JM, Shin NR, Oh SR, Ha UH, Kim JH and Ahn KS. (2016) Type III Secretion System of Pseudomonas aeruginosa affects MMP-12 and MMP-13 Expression via NF-kappaB Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. J. Infect. Dis. 214(6):962-969.
[2] Lee JH, Kim YJ, Shin HS, Lee HS, Jin S and Ha UH. (2016) Identification of D-amino acid dehydrogenase as an upstream regulator of the autoinduction of a putative acyltransferase in Corynebacterium glutamicum. J. Microbiol. 54(6):432-439.
[3] Lee Y, Kim YJ, Lee JH, Yu HE, Lee K, Jin S and Ha UH. (2016) TatC-dependent translocation of pyoverdine is responsible for the microbial growth suppression. J. Microbiol. 54(2):122-130.2015
[1]Park JW, Shin IS, Ha UH, Kim JH and Ahn KS. (2015) Pathophysiological Changes Induced by Pseudomonas aeruginosa Infection are Involved in MMP-12 and MMP-13 Upregulation in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. Infect. Immun. 83(12):4791-4799.
[2]Jia J, Bai F, Jin Y, Santostefano KE, Ha UH, Wu D, Wu W, Terada N and Jin S. (2015) Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins. Stem Cells Transl. Med. 4(8):913-926.
[3]Salcedo DE, Lee JH, Ha UH, Kim SP. (2015) The effects of antibiotics on the biofilm formation and antibiotic resistance gene transfer. Des. Water Treat. 54(13):3582-3588.2014
[1]Lee JH, Shin HS, Kim YJ, Paek SH, Jin S and Ha UH. (2014) Pseudomonas aeruginosa-induced IL-1 production is inhibited by Sophora flavescens via the NF-kappaB/inflammasome pathways. J. Microbiol. 52(12):1044-1049.
[2]Kim YJ, Shin HS, Jin S and Ha UH. (2014) Upregulaton of bradykinin receptor mediated by nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa. Korean J. Microbiol. 50(4):281-284.
[3]Kwak YH, Lee JH, Lee JH, Kwak SH, Oh SW, Paek SH, Ha UH, Seo SK. (2014) A simple and low-cost biofilm quantification method using LED and CMOS image sensor. MIMET 107:150-156. (co-corresponding)
[4]Jeon JW, Ha UH, Paek SH. (2014) In vitro inflammation inhibition model based on semi-continuous toll-like receptor biosensing. PLoS ONE. 9(8):e105212.
[5]Jeon JW, Cho IH, Ha UH, Seo SK, Paek SH. (2014) Chemiluminometric Immuno-Analysis of Innate Immune Response against Repetitive Bacterial Stimulations for the Same Mammalian Cells. Sci. Reports 4:6011.
[6]Yoo JY, Shin H, Kim TH, Choi WS, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Ha UH, Jeong JW. (2014) CRISPLD2 Is a Target of Progesterone Receptor and Its Expression Is Decreased in Women with Endometriosis. PLoS ONE. 9(6):e100481. (co-corresponding)
[7]Paek SH, Park JN, Kim DH, Kim HS, Ha UH, Seo SK, Paek SH. (2014) Semi-continuous, label-free immunosensing approach for Ca(2+)-based conformation change of a calcium-binding protein. Analyst 139(15):3781-3789.
[8]Kim YJ, Lee JH, Lee Y, Jia J, Paek SH, Kim HB, Jin S, Ha UH. (2014) Nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways. Infect. Immun. 82(8):3252-3260.
[9]Neeld D, Jin Y, Bichsel C, Jia J, Guo J, Bai F, Wu W, Ha UH, Terada N, Jin S. (2014) Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system. Microbiology 160(7):1417-1426. (co-corresponding)
[10]Kim YJ, Paek SH, Jin S, Park BS and Ha UH. (2014) A novel Pseudomonas aeruginosa-derived effector cooperates with flagella to mediate the upregulation of interleukin 8 in human epithelial cells. Microb Pathog. 66:24-28.
[11]Kim KH, Yeon SM, Kim HG, Choi HS, Kang H, Park HD, Park TW, Pack SP, Lee EH, Byun Y, Choi SE, Lee KS, Ha UH, Jung YW. (2014) Diverse influences of androgen-disrupting chemicals on immune responses mounted by macrophages. Inflammation 37(3):649-656. (co-corresponding)
[12]Kim S, Yun Z, Ha UH, Lee S, Park H, Kwon EE, Cho Y, Choung S, Oh J, Medriano CA, Chandran K. (2014) Transfer of antibiotic resistance plasmids in pure and activated sludge cultures in the presence of environmentally representative micro-contaminant concentrations. Sci Total Environ. 468-469:813-820.
[13]Kim KH, Yeon SM, Kim HG, Lee H, Kim SK, Han SH, Min KJ, Byun Y, Lee EH, Lee KS, Yuk SH, Ha UH, Jung YW. (2014) Single-Walled Carbon Nanotubes Induce Cell Death and Transcription of TNF-α in Macrophages Without Affecting Nitric Oxide Production. Inflammation 37(1):44-54. (co-corresponding)2013
[1]Shin HS, Lee JH, Paek SH, Jung YW, Ha UH. (2013) Pseudomonas aeruginosa-dependent upregulation of TLR2 influences host responses to a secondary Staphylococcus aureus infection. Pathog Dis. 69(2):149-156.
[2]Yeoa KB, Ha UH, Jung YW, Kang TJ, Pack SP. (2013) Specific Detection of Inflamed Cells using TLR1 Antibody and its Secondary Antibody-conjugated Nano-beads. Enzyme Microbial Tech. 53:223-238.
[3]Kim YJ, Shin HS, Lee JH, Jung YW, Kim HB and Ha UH. (2013) Pneumolysin-mediated expression of -defensin 2 is coordinated by p38 MAP kinase-MKP1 in human airway cells. J. Microbiol. 51(2):194-199.2012
[1]Jin GS, Yoo IH, Pack SP, Yang JW, Ha UH, Pack SH and Seo SK. (2012) Lens-free shadow image based high-throughput continuous cell monitoring technique. Biosensors Bioelectronics 38:126-131.
[2]Cho IH, Jeon JW, Paek SH, Kim DH, Shin HS, Ha UH, Seo SK and Paek SH. (2012) Toll-Like Receptor-Based Immuno-Analysis of Pathogenic Microorganisms. Anal. Chem. 84:9713-9720.
[3]Kim YJ, Lee HS and Ha UH. (2012) Effects of Cell-free Culture Fluids for the Expression of Putative Acyltransferase in Corynebacterium glutamicum. Korean J. Microbiol. 48(3):207-211.2011
[1]Shin HS and Ha UH. (2011) Up-regulation of human bradykinin B1 receptor by secreted components of Pseudomonas aeruginosa via a NF-kappaB pathway in epithelial cells. FEMS Immunol. Med. Microbiol. 63(3):418-426.
[2]Shin HS and Ha UH. (2011) Up-regulation of bradykinin B2 receptor by Pseudomonas aeruginosa via the NF-kappaB pathway. Curr. Microbiol. 63(2):138-144.
[3]Shin HS, Kim YJ, Yoo IH, Lee HS, Jin S and Ha UH. (2011) Autoinduction of a genetic locus encoding putative acyltransferase in Corynebacterium glutamicum. Biotechnol. Lett. 33(1):97-102.2010
[1]Shin HS, Yoo IH, Kim YJ, Kim HB, Jin S and Ha UH. (2010) MKP1 regulates the induction of inflammatory response by pneumococcal pneumolysin in human epithelial cells. FEMS Immunol. Med. Microbiol. 60(2):171-178.
[2]Shin HS, Yoo IH, Kim YJ, Lee JY, Kim HB, Jin S and Ha UH. (2010) MKP1 regulates the induction of MCP1 by Streptococcus pneumoniae pneumolysin in human epithelial cells. Mol. Cells 30(3):263-270.
[3]Yoo IH, Shin HS, Kim YJ, Kim HB, Jin S and Ha UH. (2010) Role of pneumococcal pneumolysin in the induction of an inflammatory response in human epithelial cells. FEMS Immunol. Med. Microbiol. 60(1):28-35.
[4]Lee SM, Lee JY, Park KJ, Park JS, Ha UH, Kim Y and Lee HS. (2010) The regulator RamA influences cmytA transcription and cell morphology. Curr. Microbiol. 61(2):92-100.1. Bacterial Pathogenesis
2. Innate Immune Defense Response
3. Host-Microbe Interaction
4. Microbe-mediated Immune Modulation
5. Bacteria-mediated Protein Delivery System
학부과정
1. BTEC209 분자세포생물학1 (Molecular Cell Biology 1; MCB1)
2. BTEC210 분자세포생물학2 (Molecular Cell Biology 1; MCB1)
3. BTEC375 세포공학1 (Cell Engineering 1-Animal Cell Culture; CE1)
4. BTEC376 세포공학2 (Cell Engineering 2-Cell Signaling; CE2)
대학원과정
1. BTK502 고급분자세포생물학
2. BTK608 동물세포배양특론
3. BTK615 세포와 세포의 상호작용
4. BTK621 세포신호전달학
5. BTK631 세포공학특수연구1
6. BTK632 세포공학특수연구2
7. BTK652 병원체와 인체 방어기작
현재
21‘ 이재후 석박통합과정
22’ 김대겸 석박통합과정
졸업생
12' 유인화 석사, CJ 제일제당 바이오기술연구소
16' 김용재 박사, 엔지켐바이오
16' 신희성 박사, 필코리아테크놀로지
19' 김경훈 박사, 제넥신
19' 허진원 석사, 이노베아션바이오
20' 이민구 석사, 나노엔텍
20' 이예지 박사, 연구교수
20' 이정훈 박사, 한국기초과학지원연구원(KBSI)
20' 전지수 박사, 한국생명공학연구원
22' 유현승 석사, 켐온