Prof.백승필
Prof.백승필
직위 또는 학위 : 교수
Tel : 044-860-1415
E-mail : spack@korea.ac.kr
연구분야 : 나노생물공학 및 생체모방공학
Seung Pil Pack, Ph.D.
Professor
Department of Biotechnology and Bioinformatics
&
President of Korea University Research-Business Foundation
Korea University Sejong Campus
&
Principle Investigator
Nano and Artificial Biotechnology Laboratory (NABL)
&
Adjunct Professor
Korea University Medical Center & Medical School
&
Director
Marine Bio-Mineralization Research Center (mBMRC, NRF)
Korea University
(w/ Hanyang Univ., Konkuk Univ., Cungnam Nat'l Univ., POSTECH., Yeungnam Univ.)
+82-44-860-1419 (Tel)
+82-44-860-1598 (Fax)
Education
최석봉교수 학술활동 Ph. D. 1997. 3. 1 - 2003. 2. 25
SchoolofChemicalEngineering,Seoul National University
Thesis: (Advisor : Prof. Young Je Yoo)
“Development of Protein Thermostabilization Strategies using Structure-base Pattern Analysis and Solvation Energy Model”M.S. 1995. 3. 1 - 1997. 2. 26
Department of Chemical Engineering, Seoul National University
Thesis: (Advisor : Prof. Young Je Yoo)
“Development of Cellobiose-utilizing Recombinant Yeast and its Application to Ethanol Production”B.S. 1991. 3. 1 - 1995. 2. 25
Department of Agricultural Chemistry, Seoul National UniversityExperience in Research
Experience in Research Director
Marine Bio-Mineralization Research Center (mBMRC), NRF, MISP, Korea
2016. 3.1- Present Professor
Department of Biotechnology and Bioinformatics, Korea University, Korea
2014. 8.1- 2015. 07.31 Visiting Professor
Institute of Collaborative Biotechnologies,
University of California, Santa Barbara CA, USA
2004
1. SeungPilPack, Kwang Myung Cho, Hyun-Sam Kang and Young Je Yoo
Development of cellobiose-utilizing yeast for ethanol production from cellulose hydrolyzate
Journal of Microbiology and Biotechnology; Vol 8 (5) pp 441-448 (1998. 10. 1)2. SeungPilPack, KyungmoonParkandYoungJeYoo
Enhancement of beta-glucosidase stability and cellobiose-usage using surface-engineered recombinant Saccharomyces cerevisiae in ethanol production
Biotechnology Letters; Vol 24 (22) pp 1919-1925 (2002. 11. 1)3. SeungPilPackand Young Je Yoo
Protein thermostability: Structure-based difference of residual properties
between thermophilic and mesophilic proteins
Journal of Molecular Catalysis B; Enzymatic; Vol 26 (3-6) pp 257-264 (2003. 12. 1)4. SeungPilPackand Young Je Yoo
Protein thermostability: Structure-based difference of amino acids between
thermophilic and mesophilic proteins
Journal of Biotechnology; Vol 111 (3) pp 269-277 (2004. 8. 5)5. SeungPilPack, Daihei Yamamoto, Tsutomu Kodaki and Keisuke Makino
Chemical synthesis of oxanine-contained oligonucleotides
Nucleic Acids Symposium Series; No 48 pp 249-250 (2004. 11. 1)2005
6. SeungPilPack, Toshinori Suzuki, Hiroshi Ide, Tsutomu Kodaki and Keisuke Makino
Reaction of NO with nucleic acid bases and its biological implications
Frontiers in Organic Chemistry; Vol 1 pp 297-341 (2005. 3. 1) (BookChapter)7. SeungPilPackand Young Je Yoo
Packing-based difference of structural features between thermophilic and mesophilic proteins
International Journal of Biological Macromolecules; Vol 35 (3-4) pp 169-174 (2005. 4. 1)8. Yoo Seong Choi,SeungPilPackand Young Je Yoo
Development of a protein microarray using sequence-specific DNA binding domain on DNA chip surface
Biochemical and Biophysical Research Communications; Vol 329 (4) pp 1315-1319 (2005. 4. 15)9. TajoAbraham*,SeungPilPack*and Young Je Yoo
(*; Equal Contribution)
Stabilization of Bacillus subtilis Lipase A by increasing the residual packing
Biocatalysis and Biotransformation; Vol 23 (3-4) pp 217-224 (2005. 9. 1)10. SeungPilPack, Mitsuru Nonogawa, Nagendra K. Kamisetty, Tsutomu Kodaki and Keisuke Makino
Biophysical and biochemical properties of oxanine-containing
oligodeoxynucleotide
Nucleic Acids Symposium Series; No 49 pp 95-96 (2005. 9. 1)11. Nagendra K. Kamisetty,SeungPilPack, Mitsuru Nonogawa, Tsutomu Kodaki and Keisuke Makino
Fabrication of efficient DNA microarray by additional surface modification and functional probe design
Nucleic Acids Symposium Series; No 49 pp 225-226 (2005. 9. 1)12. Mitsuru Nonogawa, Toshiyuki Arai, Nobuyuki Endo, SeungPilPack, Tsutomu Kodaki and Keisuke Makino
Hydrogen bond removal of pterin derivatives whose structure is similar to nucleic acids bases
Nucleic Acids Symposium Series; No 49 pp 311-312 (2005. 9. 1)13. SeungPilPack, Mitsuru Nonogawa, Tsutomu Kodaki and Keisuke Makino
Chemical synthesis and thermodynamic characterization of oxanine-containing oligodeoxynucleotides
Nucleic Acids Research; Vol 33 (18) pp 5771-5780 (2005. 9. 26)14.Yoo Seong Choi, SeungPilPack and Young Je Yoo
Development of a plasmid display system using GAL4 DNA binding domain for the in vitro screening of functional proteins
Biotechnology Letters; Vol 27 (21) pp 1707-1711 (2005. 11. 1)2006
15. Mitsuru Nonogawa, Toshiyuki Arai, Nobuyuki Endo, SeungPilPack, Tsutomu Kodaki and Keisuke Makino
Novel 6-formylpterin derivatives: chemical synthesis and O2toROSconversionactivities
Organic and Biomolecular Chemistry; Vol 4 (9) pp 1811-1816 (2006. 4. 3)16. Nagendra K. Kamisetty, SeungPilPack, Mitsuru Nonogawa, Kamakshaiah C. Devarayapalli, Tsutomu Kodaki and Keisuke Makino
Development of an efficient amine-functionalized glass platform by additional silanization treatment with alkylsilane
Analytical and Bioanalytical Chemistry; Vol 386 (6) pp1649-1656 (2006. 11.15)17. SeungPilPack, Akihiro Doi, Mitsuru Nonogawa, Nagendra K. Kamisetty, Kamakshaiah C. Devarayapalli, Tsutomu Kodaki and Keisuke Makino
Structural property and enzymatic response of oxanine in DNA strands
Nucleic Acids Symposium Series; No 50 pp 97-98 (2006.11. 20)18. Nagendra K. Kamisetty, SeungPilPack, Mitsuru Nonogawa, Kamakshaiah C. Devarayapalli, Tsutomu Kodaki and Keisuke Makino
Synthesis and application of new amine-modified oligoucleotides using H-phosphonate chemistry
Nucleic Acids Symposium Series; No 50 pp 171-172 (2006.11. 20)19. Kamakshaiah C. Devarayapalli, SeungPilPack, Nagendra K. Kamisetty, Mitsuru Nonogawa, Tsutomu Kodaki and Keisuke Makino
Development of DNA-arrayed column for sensitive and selective analysis of DNA
Nucleic Acids Symposium Series; No 50 pp 209-210 (2006.11. 20)본 연구실은 생물이 가지고 있는 독특하고 유용한 기능성 또는 구조를 산업적으로 응용하는 생물모사 ("Biomimetics") 기반의 Biotechnology를 지향한다.
특히, 새로운 기능성을 가진 생물 분자를 발굴하거나 목적에 맞는 설계 및 개량을 통한 새로운 산업용 생물복합 재료 및 효소 개발 연구를 진행하고 있다.
설계된 기능성 생물 분자 및 복합체는 고효능의 생물 약제로의 활용 뿐만 아니라 고정밀 생명 분석용 분자 프로브와 고효율 생물전환 시스템 구성용 생촉매 등으로 활용 가능하다. 또한, 인공 기능성 분자 설계를 바탕으로 생명의 근원을 분자수준에서 이해함과 더불어 새로운 개념의 기능성 창출도 시도하고 있다.
연구분야는 나노생물공학과 생체모방공학으로 주로 생체유래 DNA, RNA, 단백질, 효소 등의 분자나노수준의 고찰과 생체 모방형 설계를 통해 새로운 산업용, 의료용 바이오 소재 개발 연구를 수행하고 있다. 주요 연구과제는 C1 (CO2 , CH4) 저감 및 전환용 생물모방 촉매 개발, 모방 설계기반의 약물전달 및 조직공학 소재 개발, 바이오미네랄 유래의 유무기복합 신소재개발, Aptamer 및 변형 핵산등 기능성 분자의약 개발 등이다.
1. Protein/peptide Engineering (Rational Design, HT Screening, Directed Evolution)
2. Biomimetic or Bio-inspired Materials/Systems for Tissue Engineering & Regenerative Medicine (TERM)
3. Bio-Mineralization (BIO-MIN), Biosilica Technology, Diatom Technology
4. Modified DNA/RNA Technology, Aptamer Selection and Design for Genome Study
Members of NABL
Prof. Seung Pil Pack (Pinciplal Investigator)
Dr. Mi-Ran Ki (Research Prof.)
Dr. Abdelhamid Mohamed (Post-Doc.)
Dr. Eui-Kyoung Jang (Fresh Ph.D.)
Alaa Meligy (Researcher)
Ki-Baek Yeo (Ph.D. Student)
Ki-Ha Min (Ph.D. Student)
Nguyen Thi Khoa My (Ph.D. Student)
Ryeo Gang Son (Ph.D. Student)
Ki Sung Park (Ph.D. Student)
Sung Ho Kim (Ph.D. Student)
Jong Ki Kim (MS. Student)