Prof.이진협

Education

Ph.D. 2007-2011

Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, NC, USA

Dissertation title: Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis

Advisor: Aziz Sancar, M.D., Ph.D. Department of Biochemistry and Biophysics; 2015 Nobel Prize laureate in Chemistry

M.S. 2000-2002Department of Biochemistry, Kyungpook National University, Korea

Thesis title: Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite: Implications for cytotoxicity and alcohol-induced liver injury

Advisor: Jeen-Woo Park, Ph.D. Department of Biochemistry

B.S. 1993-1999Department of Biochemistry, Kyungpook National University, Korea

Professional Experiences

2017-present

Associate Professor, Department of Food & Biotechnology, Korea University, Korea

2016-2018present

Department Chair, Department of Food & Biotechnology, Korea University, Korea

2017-present

Associate Professor, Department of Food & Biotechnology, Korea University, Korea

2014-2017

Assistant Professor, Department of Food & Biotechnology, Korea University, Korea

2012-2014

Research Fellow, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

2011-2012

Postdoctoral Fellow, Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, NC, USA

2006-2007

Visiting Scholar, Department of Biochemistry and Molecular Pharmacology, Medical School at Worcester, University of Massachusetts, MA, USA

2004-2005

Research Associate, Department of Microbiology and Molecular Genetics, Harvard Medical School, MA, USA

2003-2004

Research Technician, Department of Pathology, The Johns Hopkins Medical School, MD, USA

2002-2003

KOSEF Research Fellowship, Kyungpook National University, Korea

2001-2002

Research Operator of Automated Biomolecule Sequencing, Institute of Genetic Engineering, Kyungpook National University, Korea

Teaching Experience

2014-present

Full-Time Instructor. The following lists are undergraduate courses taught in English: Principles of Biochemistry, Metabolic Biochemistry, Cellular Genetics, and Molecular Immunology; graduate courses taught in English: Trends in Biochemical Sciences, Signal Transduction, Molecular Pathology, Department of Food & Biotechnology, Korea University, Korea

2017

Invited Lecturer. Introduction to Food and Biotechnology for English-taught undergraduate course, Department of Food & Biotechnology, Korea University, Korea

2009-2010

T.A. Introduction to Biochemistry; Laboratory and Discussion Section, Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, NC, USA

66. Pan JH, Kim H, Beane Kaleigh B, Montalbano A, Lee JH, Kim YJ, Kim JH, Kong B, Kim S, JW Park, Shin E, Kim JK. IDH2 deficiency aggravates fructose-induced NAFLD by modulating hepatic fatty acid metabolism and activating inflammatory signaling in female mice. Nutrients. [Under Review] (IF: 3.550).

65. Cho HT, Kim JH, Heo W, Lee HS, Lee JH, Lee JH, Kim YJ. Explosively puffed ginseng ameliorates ionizing radiation-induced injury of colon by reducing oxidative stress-related apoptotic cell execution in mice. Am J Chin Med. [Under Review] (IF: 3.222).

64. Cha H, Lee S, Lee JH, Park JW. Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity in mice. Food Chem Toxicol. [Under Review] (IF: 3.8).

63. Park JH, Ku HJ, Lee JH*, Park JW*. IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis. Redox Biol. 2018 Apr 6;17:16-24. *These authors equally contributed as corresponding authors (IF: 6.337).

62. Wu S, Meng S, Fung T, Chan AT, Liang G, Giovannucci E, De vivo I, Lee JH*, Nan H*. Diet, cigarette smoke, and leukocyte mitochondrial DNA copy number. Am J Clin Nutr. [Under Review] *These authors equally contributed as corresponding authors (IF: 6.926).

61. Kim JK, Park JH, Ku HJ, Kim SH, Lim YJ, Park JW*, Lee JH*. Naringin protects acrolein-induced pulmonary toxicity through modulating apoptotic signaling and inflammation signaling pathways in mice. J Nutr Biochem. [Under Review] *These authors equally contributed as corresponding authors (IF: 4.518).

60. Park JH, Ku HJ, Kim JK, Park JW*, Lee JH*. Amelioration of high fructose-induced cardiac hypertrophy by naringin. Sci Rep. [Accepted] *These authors equally contributed as corresponding authors (IF: 4.259).

59. Moon J, Lee HS, Kim JH, Lee JH, Choi MH. Supported liquid extraction coupled to gas chromatography-selective mass spectrometric scan modes for serum steroid profiling. Anal. Chim Acta. [Accepted] (IF: 4.95).

58. Lim YJ, Kim JH, Pan JH, Kim JK, Park TS, Kim YJ, Lee JH*, Kim JH*. Naringin protects pancreatic -cells against oxidative stress-induced apoptosis by inhibiting both intrinsic and extrinsic pathways in insulin-deficient diabetic mice. Mol Mutr Food Res. 2018 Jan doi:10.1002/mnfr.201700810. *These authors equally contributed as corresponding authors (IF: 4.323).

57. Park JH, Ku HJ, Lee JH*, Park JW*. Idh2 deficiency exacerbates acrolein-induced lung injury through mitochondrial redox environment deterioration. Oxid Med Cell Longev. 2017 Dec 2017:7126872. *These authors equally contributed as corresponding authors (IF: 4.593).

56. Choudhry QN, Kim JH, Cho HT, Heo W, Lee J, Lee JH*, Kim YJ*. Ameliorative effect of black ginseng extract against oxidative stress-induced cellular damages in mouse hepatocytes. J Ginseng Res. [In Press] *These authors equally contributed as corresponding authors (IF: 4.082).

55. Pan JH, Lim YJ, Kim JH, Lee KY, Shin HJ, Kim JK*, Lee JH*, Kim YJ*. Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation. PLoS One. 2017 Nov 27;12(11):e0188381. *These authors equally contributed as corresponding authors (IF: 3.057).

54. Lee SJ, Cha H, Lee S, Kim H, Park JH, Ku HJ, Kim SH, Park JH, Lee JH, Park KM, Park JW. IDH2 deficiency accelerates renal dysfunction in aged mice. Biochem Biophys Res Commun. 2017 Nov 4;493(1):34-39. (IF: 2.371).

53. Lim HJ, Kim MS, Kim DS, Pan JH, Kim YJ, Lee JH, Shin EC, Kim JK. Blood pressure lowering effects of Alcalase-hydrolyzed camellia seed hull in vitro and in spontaneous hypertensive rats. J. Med. Food. 2017 Jul;20(7):720-723. (IF: 1.955).

52. Cho HT, Kim JH, Lee JH, Kim YJ. Effects of Panax ginseng extracts prepared at different steaming times on thermogenesis in rats. J Ginseng Res. 2017 Jul;41(3):347-352. (IF: 4.082).

51. Lee SJ, Cha H, Kim H, Lee JH*, Park JW*. Amelioration of late-onset hepatic steatosis in IDH2-deficient mice. Free Radic Res. 2017 May 5:1-7. doi: 10.1080/10715762.2017.1320554. *These authors equally contributed as corresponding authors (IF: 3.188).

50. Cha H, Lee S, Kim SH, Kim H, Lee DS, Lee HS, Lee JH*, Park JW*. Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis. Redox Biol. 2017 May 20;13:32-38.*These authors equally contributed as corresponding authors (IF: 6.337).

49. Pan JH, Brenn Abernathy, Kim YJ, Lee JH, Kim JH, Shin EC, Kim JK. Cruciferous vegetables and colorectal cancer prevention through microRNA regulation. Crit Rev Food Sci Nutr. 2017 Apr 10:0. doi: 10.1080/10408398.2017.1300134 (IF: 5.492).

48. Lee HS, Lee SJ, Yu HJ, Lee JH*, Cho HY*. Fermentation with Lactobacillus enhances the preventive effect of garlic extract on high fat diet-induced hepatic steatosis in mice. J Funct Foods. 2017 Mar;30:125-133. *These authors equally contributed as corresponding authors (IF: 3.973).

47. Kim SH, Kim H, Ku HJ, Park JH, Cha H, Lee S, Lee JH*, Park JW*. Oxalomalate reduces expression and secretion of vascular endothelial growth factor in the retinal pigment epithelium and inhibits angiogenesis: Implications for age-related macular degeneration. Redox Biol. 2016 Dec;10:211-220. *These authors equally contributed as corresponding authors (IF: 6.337).

46. Lee SJ, Kim SH, Park KM, Lee JH*, Park JW*. Increased obesity resistance and insulin sensitivity in mice lacking the isocitrate dehydrogenase 2 gene. Free Radic Biol Med. 2016 Oct;99:179-188. *These authors equally contributed as corresponding authors (IF: 5.784).

45. Lee HS, Lim WC, Lee SJ, Lee SH, Lee JH, Cho HY. Antiobesity effect of garlic extract fermented by Lactobacillus plantarum BL2 in diet-induced obese mice. J. Med. Food. 2016 Sep;19(9):823-9. (IF: 1.955).

44. Pan JH, Lee KY, Kim JH, Shin H, Lee JH*, Kim YJ*. Prunus mume Sieb. et Zucc. Fruit ameliorates alcoholic liver injury in mice by inhibiting apoptosis and inflammation through oxidative stress. J Funct Foods. 2016 Aug;25:135-148. *These authors equally contributed as corresponding authors (IF: 3.973).

43. Choudhry QN, Kim MJ, Kim TG, Pan JH, Kim JH, Par SJ, Lee JH, Kim YJ. Saponin-based nanoemulsification improves the antioxidant properties of vitamin A and E in AML-12 cells. Int J Mol Sci. 2016 Aug 26;17(9). Pii: E1406 (IF: 3.257).

42. Kim H, Kim SH, Cha H, Kim SR, Lee JH*, Park JW*. IDH2 deficiency promotes mitochondrial dysfunction and dopaminergic neurotoxicity: Implications for Parkinson’s disease. Free Radic Res. 2016 Aug 50(8):853-60. *These authors equally contributed as corresponding authors (IF: 3.188).

41. Lee HS, Lim WC, Lee SJ, Lee SH, Yu HJ, Lee JH, Cho HY. Hepatoprotective effects of lactic acid-fermented garlic extract against acetaminophen-induced acute liver injury in rats. Food Sci Biotech. 2016 Jun 25(3):867-873. (IF: 0.9)

40. Park JB, Nagar H, Choi S, Jung SB, Kim HW, Kang SK, Lee JW, Lee JH, Park JW, Irani K, Jeon BH, Song HJ, Kim CS. IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function. Free Radic Biol Med. 2016 May;94:36-46 (IF: 5.784).

39. Pan JH, Kim JH, Kim HM, Lee ES, Shin DH, Kim S, Shin M Kim SH, Lee JH, Kim YJ. Acetic acid enhances endurance capacity of exercise-trained mice by increasing skeletal muscle oxidative properties. Biosci Biotechnol Biochem. 2015 Sep;79(9):1535-41.

38. Park JH, Lee JH, Park JW. Attenuated SAG expression exacerbates 4-hydroxy-2-nonenal-induced apoptosis and hypertrophy of H9c2 cardiomyocytes. Free Radic Res. 2015 Apr 49(8):962-72 (IF: 3.188).

37. Ku HJ, Ahn Y, Lee JH, Park KM, Park JW. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice. Free Radic Biol Med. 2015 Mar;80:84-92 (IF: 5.784).

36. Kim SH, Yoo YH, Lee JH, Park JW. Mitochondrial NADP+-dependent isocitrate dehydrogenase knockdown inhibits tumorigenicity of melanoma cells. Biochem Biophys Res Commun. 2014 Aug 22;451(2):246-51 (IF: 2.371).

35. Kim TS, Park JE, Shukla A, Choi SH, Murugan RN, Lee JH, Ahn M, Rhee KS, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS. Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4849-57 (IF: 9.674).

34. Lee JH, Gaddameedhi S, Ozturk N, Ye R, Sancar A. DNA damage-specific control of cell death by cryptochrome in p53 mutant Ras-transformed cells. Cancer Res. 2013 Jan 15;73(2):785-91 (IF: 9.329).

33. Lee JH, Sancar A. Regulation of apoptosis by the circadian clock through NF-κB signaling¶. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12036-41. (This article was recommended by Faculty of 1000 Biology.) (IF: 9.674).

32. Lee JH, Sancar A. Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis¶. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10668-72. (PNAS selected this article for the cover and commissioned a “commentary.”) (IF: 9.674).

31. Sancar A, Lindsey-Boltz LA, Kang TH, Reardon JT, Lee JH, Ozturk N. Circadian clock control of the cellular response to DNA damage. FEBS Lett. 2010 Jun 18;584(12):2618-25 (IF: 3.519).

30. Choe SK, Lu P, Nakamura M, Lee JH, Sagerström CG. Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. Dev Cell. 2009 Oct;17(4):561-7 (IF: 9.338).

29. Guogas LM, Kennedy SA, Lee JH, Redinbo MR. A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer. J Mol Biol. 2009 Feb 20;386(2):554-68 (IF: 4.517).

28. Ozturk N*, Lee JH*, Gaddameedhi S, Sancar A. Loss of cryptochrome reduces cancer risk in p53 mutant mice¶. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2841-6. *These authors contributed equally to this work. (This article was recommended by Faculty of 1000 Biology; J. Natl. Cancer Inst. published a comprehensive news article on the paper.) (IF: 9.674).

27. Yang ES, Lee JH, Park JW. Ethanol induces peroxynitrite-mediated toxicity through inactivation of NADP+-dependent isocitrate dehydrogenase and superoxide dismutase. Biochimie. 2008 Sep;90(9):1316-24 (IF: 3.017).

26. Park YS*, Lee JH*, Hung CF, Wu TC, Kim TW. Enhancement of antibody responses to Bacillus anthracis protective antigen domain IV by use of calreticulin as a chimeric molecular adjuvant. Infect Immun. 2008 May;76(5):1952-9. * These authors contributed equally to this work (IF: 3.731).

25. Lee JH, Tak JK, Park KM, Park JW. N-t-Butyl hydroxylamine regulates ionizing radiation-induced apoptosis in U937 cells. Biochimie. 2007 Dec;89(12):1509-16 (IF: 3.017).

24. Lee JH, Kim SY, Kil IS, Park JW. Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase. J Biol Chem. 2007 May 4;282(18):13385-94 (IF: 4.258).

23. Lee JH, Park JW. Oxalomalate regulates ionizing radiation-induced apoptosis in mice. Free Radic Biol Med. 2007 Jan 1;42(1):44-51 (IF: 5.784).

22. Kang TH, Lee JH, Song CK, Han HD, Shin BC, Pai SI, Hung CF, Trimble C, Lim JS, Kim TW, Wu TC. Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Res. 2007 Jan 15;67(2):802-11 (IF: 9.329).

21. Kang TH, Lee JH, Noh KH, Han HD, Shin BC, Choi EY, Peng S, Hung CF, Wu TC, Kim TW. Enhancing dendritic cell vaccine potency by combining a BAK/BAX siRNA-mediated antiapoptotic strategy to prolong dendritic cell life with an intracellular strategy to target antigen to lysosomal compartments. Int J Cancer. 2007 Apr 15;120(8):1696-703. (IF: 6.513)

20. Kang TH, Lee JH, Bae HC, Noh KH, Kim JH, Song CK, Shin BC, Hung CF, Wu TC, Park JS, Kim TW. Enhancement of dendritic cell-based vaccine potency by targeting antigen to endosomal/lysosomal compartments. Immunol Lett. 2006 Aug 15;106(2):126-34 (IF: 5.531).

19. Peng S, Kim TW, Lee JH, Yang M, He L, Hung CF, Wu TC. Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life. Hum Gene Ther. 2005 May;16(5):584-93 (IF: 4.062).

18. Kim TW, Lee JH, He L, Boyd DA, Hung CF, Wu TC. DNA vaccines employing intracellular targeting strategies and a strategy to prolong dendritic cell life generate a higher number of CD8+ memory T cells and better long-term antitumor effects compared with a DNA prime-vaccinia boost regimen. Hum Gene Ther. 2005 Jan;16(1):26-34 (IF: 4.062).

17. Kim TW, Lee JH, He L, Boyd DA, Hardwick JM, Hung CF, Wu TC. Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency. Cancer Res. 2005 Jan 1;65(1):309-16 (IF: 9.329).

16. Kim TW, Lee JH, Hung CF, Peng S, Roden R, Wang MC, Viscidi R, Tsai YC, He L, Chen PJ, Boyd DA, Wu TC. Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus. J Virol. 2004 May;78(9):4638-45 (IF: 4.606).

15. Lee JH, Park JW. The effect of alpha-phenyl-N-t-butylnitrone on ionizing radiation-induced apoptosis in U937 cells. Free Radic Res. 2005 Dec;39(12):1325-33 (IF: 2.949).

14. Lee JH, Lee YM, Park JW. Regulation of ionizing radiation-induced apoptosis by a manganese porphyrin complex. Biochem Biophys Res Commun. 2005 Aug 26;334(2):298-305 (IF: 2.371).

13. Kil IS*, Lee JH*, Shin AH, Park JW. Glycation-induced inactivation of NADP+-dependent isocitrate dehydrogenase: implications for diabetes and aging. Free Radic Biol Med. 2004 Dec 1;37(11):1765-78. *These authors contributed equally to this work (IF: 5.784).

12. Lee JH, Park JW.A manganese porphyrin complex is a novel radiation protector. Free Radic Biol Med. 2004 Jul 15;37(2):272-83 (IF: 5.784).

11. Lee JH, Park JW. Role of thioredoxin peroxidase in aging of stationary cultures of Saccharomyces cerevisiae. Free Radic Res. 2004 Mar;38(3):225-31 (IF: 2.949).

10. Lee JH, Kim IS, Park JW. The use of N-t-butyl hydroxylamine for radioprotection in cultured cells and mice. Carcinogenesis. 2004 Aug;25(8):1435-42 (IF: 4.874).

9. Lee JH, Park JW. Protective role of alpha-phenyl-N-t-butylnitrone against ionizing radiation in U937 cells and mice. Cancer Res. 2003 Oct 15;63(20):6885-93 (IF: 9.329).

8. Lee JH, Yang ES, Park JW. Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury. J Biol Chem. 2003 Dec 19;278(51):51360-71 (IF: 4.258).

7. Park JE, Yang JH, Yoon SJ, Lee JH, Yang ES, Park JW. Lipid peroxidation-mediated cytotoxicity and DNA damage in U937 cells. Biochimie. 2002 Dec;84(12):1199-205 (IF: 3.017).

6. Kim SY*, Lee JH*, Yang ES, Kil IS, Park JW. Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage. Biochem Biophys Res Commun. 2003 Feb 14;301(3):671-4. * These authors contributed equally to this work (IF: 2.371).

5. Park HS, Lee SM, Lee JH, Kim YS, Bae YS, Park JW. Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity. Biochem J. 2001 Sep 15;358(Pt 3):783-90 (IF: 3.562).

4. Kim YS, Lee JH, Park JW, Bae YS. Regulation of protein kinase CKII by direct interaction with the C-terminal region of p47(phox). Biochem Biophys Res Commun. 2001 Aug 10;286(1):87-93 (IF: 2.371).

3. Lee JH, Choi IY, Kil IS, Kim SY, Yang ES, Park JW. Protective role of superoxide dismutases against ionizing radiation in yeast. Biochim Biophys Acta. 2001 May 3;1526(2):191-8 (IF: 5.083).

2. Lee JH, Lee KS, Chung T, Park JW. C-terminal region of the cytosolic subunit p47(phox) is a primary target of conformational change during the activation of leukocyte NADPH oxidase. Biochimie. 2000 Aug;82(8):727-32 (IF: 3.017).

1. Lee JH, Park JW. Conformational changes in truncated p47phox proteins monitored by fluorescent labeling. J Protein Chem. 2000 Nov;19(8):643-8. (IF: 1.46)

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